Effect of Bovine Interferon-7 on Progesterone Concentrations in Body Temperature and Plasma Cyclic Dairy Cows
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چکیده
We examined the effect of intramuscular injections of recombinant bovine interferon-7 on basal body temperature and plasma concentrations of progesterone in cows. Six mature, nonlactating Holstein cows were synchronized for estrus and assigned randomly to a replicated 3 x 3 Latin square design to receive 0, 1, or 5 mg of recombinant bovine interferon-7 intramuscularly on d 9, 12, or 15 of the estrous cycle. Rectal temperatures were measured, and blood was collected just prior to injection, at hourly intervals for 8 h, and at 10 and 12 h after injection. Treatment with 1 and 5 mg of recombinant bovine interferon-.z caused a rise in body temperature that peaked at 6 h (39.5 f .13"C) and 4 h (40.3 * .13"C), respectively. Analysis of homogeneity of regression for response curves indicated that 5 mg of recombinant bovine interferon-7 decreased plasma progesterone concentrations. This effect was not detected for the 1-mg dose of recombinant bovine interferon-7. Intramuscular administration of 5 mg of recombinant bovine interferon-7 caused a hyperthermic response that was temM. D. MEYER, P. J. HANSEN, and W. W. THATCHER1 Department of Dairy and Poultry Sciences University of Florida Gainesville 3261 1-0920 M. DROST Large Animal Clinical Sciences College of Veterinary Medicine Gainesville 3261 14136 R. M. ROBERTS Department of Animal Sciences University of Missouri 158 Animal Sciences Research Center Columbia 65211 Received December 7, 1994. Accepted February 22, 1995. 'To whom correspondence should be addressed: PO Box 110920. porally associated with the decrease in plasma progesterone. Intramuscular administration of 1 mg of recombinant bovine interieron-.r caused a slight rise in temperature occurring 4 h later than that caused by 5 mg of recombinant bovine interferon-7, and no decrease in plasma progesterone was detected. Recombinant bovine interferon-7, administered at a 1-mg dose, warrants further study to determine whether it will alter survival rate of cattle embryos. (
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